Diane P. Genereux

This study uses untargeted sequencing to analyze population genetics and pathogen surveillance in timber rattlesnakes, finding genetic distinctness and a color variation locus linked to ALDH4A1.

This study evaluates how preanalytical factors affect liquid biopsy in canine cancer models, finding that tumor content and metrics vary by blood draw location and cancer type.

This study identifies blood biomarkers and genetic factors associated with aging in dogs using genomic and phenotypic data from 7,627 dogs.

This study analyzes multi-omic data from canine osteosarcoma to identify inter-patient heterogeneity and immune enrichment in metastatic lesions.

This study compares genomic features of dog and human cancers across multiple types, finding widespread shared mutational signatures and genes, suggesting dogs as valuable models for precision oncology.

The paper identifies proteins and regulatory elements associated with vocal learning by analyzing bat neural activity and epigenomic data.

TOGA integrates gene annotation and orthology inference across hundreds of genomes, improving ortholog detection and creating large comparative gene resources.

A machine learning approach identifies enhancer-phenotype associations across mammals, revealing links to brain size and behavior evolution.

The paper curates TE content in 248 mammalian genomes, finding trends in recent TE accumulation and associations with dietary habits.

A 240-species placental mammal alignment resolves constraint to single bases, estimating at least 10.7% of the human genome is constrained, with 48.5% of constrained bases unannotated.

The paper uses evolutionary constraint scores to identify functional genomic regions and finds they are enriched for variants associated with common diseases.

The paper identifies bats as a hotspot for horizontal transfer of DNA transposons, finding over 200 putative elements and shared transposons across mammals and reptiles.

The paper predicts the broad host range of SARS-CoV-2 by analyzing ACE2 conservation across vertebrates and identifying high-risk species.

The paper improves the Cactus multiple-genome aligner to handle large numbers of vertebrate genomes with high accuracy and better orthology resolution.

The paper introduces a framework to quantify DNA methylation stability and flexibility in mammalian cells, finding that differentiated cells have higher stability than stem cells.

The paper identifies OCD-associated genes by combining evolutionary and functional data with targeted sequencing in humans and animal models.