Inhibition of NF-κB Signaling by the Reactive Glycolytic Metabolite Methylglyoxal
Caroline R. Stanton, Woojin Choi, R. Luke Wiseman, Michael J. Bollong
This study shows that inhibiting PGK1 with CBR-470-2 reduces NF-κB signaling by increasing methylglyoxal, which inactivates NF-κB proteins.
bioRxiv · May 13, 2025 · PreprintBiochemistry