A binding site for the antibiotic GE81112 in the ribosomal mRNA channel
Andreas Schedlbauer, Xu Han, Wouter van Bakel, Tatsuya Kaminishi, Borja Ochoa-Lizarralde, Idoia Iturrioz, Retina Çapuni, Ransford Parry, Ronny Zegarra-Peña, David Gil‐Carton, Jorge Pedro López-Alonso, Kristina Barragán Sanz, Letizia Brandi, Claudio Orlando Gualerzi, Paola Fucini, Sean R. Connell
This study identifies the binding site of the antibiotic GE81112 in the ribosomal mRNA channel using cryoEM, showing it acts allosterically to inhibit translation initiation.
mBio · Oct 24, 2025Peer-reviewedMicrobiology