Sean R. Connell

This study identifies the binding site of the antibiotic GE81112 in the ribosomal mRNA channel using cryoEM, showing it acts allosterically to inhibit translation initiation.

The paper investigates hibernating ribosomes in the microsporidian parasite Spraguea lophii using cryoET and cryoEM, revealing a unique dimeric structure and the role of MDF1 in translation inhibition.

This study determines the structure of KBP-7072 bound to the 30S ribosomal subunit, showing it inhibits protein synthesis by binding to the primary tetracycline site and interacting uniquely with the subunit.