Spatially barcoding biochemical reactions using DNA nanostructures unveil a major contact mechanism in proximity labeling
Zhe Yang, Yu Zhang, Yuxin Fang, Yuan Zhang, Jiasheng Du, X. L. Shen, Kecheng Zhang, Peng Zou, Zhixing Chen
The paper uses DNA nanostructures to measure the labeling radii of TurboID and APEX2, revealing contact-dependent mechanisms rather than diffusive labeling.
Nature Chemical Biology · Dec 24, 2025Peer-reviewedBiochemistry