Zhixing Chen

This paper introduces SIM-fdFLIM, a super-resolution FLIM method that preserves ratio accuracy and enables high-speed, high-resolution live-cell lifetime imaging.

The paper uses live-cell imaging and analysis in mouse embryonic stem cells to show that transcriptional bursting is linked to dynamic merging of enhancer- and promoter-associated regulatory assemblies.

This paper introduces DeepUI, a physics-driven framework that reconstructs isotropic 3D fluorescence images from undersampled axial data, achieving high performance even under challenging conditions.

This paper introduces FA-SIM, a super-resolution microscopy technique that quantitatively maps intracellular microenvironment and cytoskeletal dynamics with high accuracy and low phototoxicity.

The paper uses DNA nanostructures to measure the labeling radii of TurboID and APEX2, revealing contact-dependent mechanisms rather than diffusive labeling.

This study investigates FUS-ERG fusion oncoprotein-DNA co-condensates, revealing nested asymmetric phase separation and their potential for DNA-based information manipulation.

This paper introduces PK Mem dyes for time-lapse fluorescence imaging, showing reduced phototoxicity and improved photostability for live and fixed cell imaging.

The paper introduces a far-red dopamine sensor, HaloDA1.0, enabling multiplex imaging of neurochemical networks in vivo with high sensitivity and versatility.

This paper introduces a new class of fluorophores with enhanced photostability, solubility, and tunable properties for advanced biological imaging applications.

DeepCristae restores mitochondria cristae in low-resolution microscopy images using a CNN trained on STED data and specialized loss functions.

This paper introduces Gentle Rhodamines with reduced phototoxicity for live-cell imaging, enabling time-lapse and voltage imaging with less cellular damage.

The paper introduces DQmB-HA, a method for sensitive quantification of carboxylic acid metabolites, enabling single-cell analysis and blood sample profiling in mice and humans.