Peng Zou

Spatially barcoding biochemical reactions using DNA nanostructures unveil a major contact mechanism in proximity labeling

The paper uses DNA nanostructures to measure the labeling radii of TurboID and APEX2, revealing contact-dependent mechanisms rather than diffusive labeling.

Controllable Gap Junctions by Vitamin B12 and Light

This paper introduces CarGAP, a chemo-optogenetic tool to reversibly control gap junctions in vertebrates and invertebrates with spatiotemporal precision.

Structural Role of Stomatin in Organizing Functional Membrane Microdomains

This study determines the cryo-EM structure of stomatin, revealing its role in organizing functional membrane microdomains and identifying associated proteins involved in cell migration and vesicle trafficking.

A photostable genetically encoded voltage indicator for imaging neural activities in tissue and live animals

The paper introduces Vega, a photostable GEVI with high sensitivity and fast response, enabling high-fidelity voltage imaging in tissue and live animals.

A Palette of Bridged Bicycle-Strengthened Fluorophores

This paper introduces a new class of fluorophores with enhanced photostability, solubility, and tunable properties for advanced biological imaging applications.

Photoactivated SOPP3 enables APEX2-mediated proximity labeling with high spatio-temporal resolution in live cells

This paper introduces a new proximity labeling method using photoactivated SOPP3 and APEX2 to enable high spatio-temporal resolution in live cells without exogenous H2O2 or cytotoxicity.

Gentle rhodamines for live-cell fluorescence microscopy

This paper introduces Gentle Rhodamines with reduced phototoxicity for live-cell imaging, enabling time-lapse and voltage imaging with less cellular damage.

Solaris: a panel of bright and sensitive hybrid voltage indicators for imaging membrane potential in cultured neurons

The paper introduces Solaris, a hybrid voltage indicator with improved sensitivity for imaging membrane potential in cultured neurons.

Immunoproximity biotinylation reveals the axon initial segment proteome

The paper defines the axon initial segment proteome using immunoproximity biotinylation and identifies SCRIB as a highly enriched AIS protein.

Bright and sensitive red voltage indicators for imaging action potentials in brain slices and pancreatic islets

The paper introduces two red-emitting genetically encoded voltage indicators (GEVIs) that improve sensitivity, brightness, and photostability for imaging action potentials in brain slices and pancreatic islets.

MRGPRX4 is a novel bile acid receptor in cholestatic itch

The paper identifies MRGPRX4 as a novel bile acid receptor involved in cholestatic itch, showing its activation by bile acids and its role in itch induction in humans.

All-optical electrophysiology for high-throughput functional characterization of human iPSC-derived motor neuron model of ALS

The paper introduces an all-optical electrophysiology method called Optopatch to functionally characterize human iPSC-derived motor neurons in ALS models, finding altered electrophysiological properties in SOD1 A4V mutants.