Seipin traps triacylglycerols to facilitate their nanoscale clustering in the ER membrane
X. Prasanna, V. T. Salo, S. Li, K. Ven, H. Vihinen, E. Jokitalo, I. Vattulainen, E. Ikonen
This study shows seipin traps triacylglycerols in the ER membrane via its luminal hydrophobic helices, facilitating their nanoscale clustering and promoting TAG transfer to lipid droplets.
bioRxiv · Oct 26, 2020Cell Biology