I. Vattulainen

Exposure to aldehyde cherry e-liquid flavouring and its vape by-product disrupts pulmonary surfactant biophysical function

This study shows that benzaldehyde and its by-product, benzaldehyde propylene glycol acetal, disrupt pulmonary surfactant biophysical function by interacting with surfactant proteins SP-B and SP-C.

Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space

This paper identifies C95-C95 disulfide-bridge-mediated FGF2 dimerization as essential for membrane translocation and oligomer formation, while C77 is involved in Na,K-ATPase binding.

Protein Crowding and Cholesterol Increase Cell Membrane Viscosity in a Temperature Dependent Manner

This study uses molecular dynamics simulations to investigate how protein crowding, cholesterol, lipid composition, and temperature affect membrane viscosity, finding that cholesterol and protein concentration have larger effects than lipid chain properties.

Surfactant Proteins SP-B and SP-C in Pulmonary Surfactant Monolayers: Physical Properties Controlled by Specific Protein-Lipid Interactions

This study uses molecular dynamics simulations and experimental techniques to investigate how surfactant proteins SP-B and SP-C interact with lipid monolayers, revealing their role in modulating surface pressure and phase behavior.

Targeting a broad spectrum of KRAS-mutant cancers by hyperactivation-induced cell death

This study identifies SHANK3 as a RAS interactor that limits oncogenic KRAS signaling, and shows that disrupting its interaction with KRAS induces cell death in KRAS-mutant cancers.

Regulation of cell dynamics by rapid transport of integrins through the biosynthetic pathway

This study shows that integrin transport through the biosynthetic pathway rapidly alters adhesion receptor availability, enabling localized cell spreading and focal adhesion growth.

Dissecting the mechanisms of environment sensitivity of smart probes for quantitative assessment of membrane properties

This study investigates the sensitivity of three environment-sensitive probes to biophysical membrane properties using model systems and simulations.

Cholesterol promotes both head group visibility and clustering of PI(4,5)P2 driving unconventional secretion of Fibroblast Growth Factor 2

This study shows cholesterol enhances FGF2 secretion by promoting PI(4,5)P2 clustering and membrane pore formation.

Conformational dynamics regulate SHANK3 actin and Rap1 binding

This study shows SHANK3 binds actin and Rap1 through its SPN domain, with conformational changes regulating this interaction and affecting cellular processes like filopodia formation and autism-related phenotypes.

Seipin traps triacylglycerols to facilitate their nanoscale clustering in the ER membrane

This study shows seipin traps triacylglycerols in the ER membrane via its luminal hydrophobic helices, facilitating their nanoscale clustering and promoting TAG transfer to lipid droplets.

Determinants for forming a supramolecular myelin-like proteolipid lattice

This study uses structural and functional analyses to reveal how myelin protein P2 forms a supramolecular lattice between lipid bilayers, identifying key residues and interactions involved in membrane binding.

The α1 subunit of the Na,K-ATPase acts upstream of PI(4,5)P2 facilitating unconventional secretion of Fibroblast Growth Factor 2 from tumor cells

This study identifies a direct interaction between FGF2 and the Na,K-ATPase α1 subunit, showing it facilitates FGF2 membrane translocation upstream of PI(4,5)P2.

Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain

The paper reports the cryo-EM structure of the insulin receptor ectodomain with four insulin molecules, revealing two binding sites and a T-shaped conformation.