A high-throughput approach to identify reproductive toxicants among environmental chemicals using an in vivo evaluation of gametogenesis in budding yeast Saccharomyces cerevisiae
R. Kumar, A. Oke, B. Rockmill, M. de Cruz, R. Verduzco, X. W. Madeira, D. Abrahamsson, J. Robinson, P. Allard, T. Woodruff, J. Fung
This study develops a high-throughput yeast assay to identify reproductive toxicants among environmental chemicals, finding 57 toxic chemicals and a significant association with mammalian toxicity.
bioRxiv · Jan 25, 2022 · PreprintPharmacology & Toxicology