Lithocholic acid targets TULP3 to activate sirtuins and AMPK to retard ageing
Q. Qu, Y. Chen, Y. Wang, S. Long, W. Wang, H.-Y. Yang, J. Wu, M. Li, X. Tian, X. Wei, Y.-H. Liu, S. Xu, C. Yang, Z. Wu, X. Huang, , Y. Yu
This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.
bioRxiv · Dec 7, 2023 · PreprintPhysiology