A high-throughput immunopeptidome platform for MHC II alleles to characterize antigen-specific CD4 + T cells
Jing Chen, Xu Zhu, Jun Huo, Shang Wu, Ting Zhou, Chunyu Cheng, Hao Dong, Yan Li, Xianchi Dong, Yuxin Chen
The paper develops EliteMHCII, a high-throughput platform to identify MHC II epitopes and assess peptide binding affinity, showing high-affinity peptides correlate with strong CD4+ T cell responses.
bioRxiv · Jun 5, 2025Biochemistry