Author

Yuxin Chen

Xuzhou Medical College

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Biology Disciplines

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Evolutionary Biology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Chung-I Wu· 2 shared Chong Hong· 1 shared Christian WolfrumiD· 1 shared Chunyu Cheng· 1 shared Hao Dong· 1 shared Huixia ZhangiD· 1 shared Jiayu Wu· 1 shared Jin BaiiD· 1 shared

Activity by Year

2017-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersEvolutionary Biology

Chung-I Wu

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4 papers

Recent·Most cited

TRIM21 licenses pancreatic acinar fate by modulating BiP phase state through VCP-dependent retrotranslocation

Yifu Zhu, Ronghua Yu, Xue Luan, Yan Huang, 李权达, Yuran Zhao, Huixia Zhang, Xinghua Huang, Yuxin Chen, Xiaoya Wu, Zhongjun Zhao, Jingke Ding, Jing Xue, Chong Hong, Liye Ma, , Wenjie Ge

This study identifies TRIM21 as a regulator of BiP phase state under ER stress, preventing solidification and maintaining UPR function, with implications for pancreatic cancer.

bioRxiv · Oct 1, 2026 · PreprintCell Biology

A high-throughput immunopeptidome platform for MHC II alleles to characterize antigen-specific CD4 + T cells

Jing Chen, Xu Zhu, Jun Huo, Shang Wu, Ting Zhou, Chunyu Cheng, Hao Dong, Yan Li, Xianchi Dong, Yuxin Chen

The paper develops EliteMHCII, a high-throughput platform to identify MHC II epitopes and assess peptide binding affinity, showing high-affinity peptides correlate with strong CD4+ T cell responses.

bioRxiv · Jun 5, 2025Biochemistry

Gene regulatory network rewiring by an adaptively evolving microRNA cluster in Drosophila

Yang Lyu, Zhongqi Liufu, Juan Xiao, Yuxin Chen, Chung-I Wu, Tian Tang

This study shows how a newly evolved microRNA cluster in Drosophila rewires gene regulatory networks through sequence changes, while maintaining a conserved target pool.

bioRxiv · Nov 30, 2017 · PreprintEvolutionary Biology

From foodwebs to gene regulatory networks (GRNs) - weak repressions by microRNAs confer system stability

Yuxin Chen, Yang Shen, Stefano Allesina, Chung-I Wu

The paper uses foodweb theory to show weak microRNA repressions enhance gene regulatory network stability, supported by yeast and human transcriptome data and simulations.

bioRxiv · Aug 16, 2017 · PreprintEvolutionary Biology