Rational antigen engineering and mucosal delivery design for next-generation RSV vaccines
Wangjun Fu, Desheng Liu, Xiangfei Shan, Chujun Ding, Hui Zhai, Lu Jiang, Yuqing Zhou, 毛文强, Jie Deng, Mingkai Li, Yaling Hu, Zhe Lv, Yufei Xia, Xiangxi Wang
This paper develops a structure-guided RSV vaccine platform with stabilized prefusion F immunogens and mucosal delivery, showing protection in animal models and advancing to clinical trials.
bioRxiv · Jul 28, 2026 · PreprintMicrobiology