Super Enhancer-driven LncRNA UNC5B-AS1 Inhibits Inflammatory Phenotypic Transition in Smooth Muscle Cells via Lactylation Modification
Xiangrui Zhu, Xiangming Pang, Xiaoying Wang, Xiaoyu Guan, Zhaosi Wang, Lixin Zhang, Xiaodong Zheng, Fei Li, Jian Mei, Langlin Ou, Yuxiang Liu, Zitong Meng, Yingli Chen, Cui Ma
This paper identifies UNC5B-AS1, a super enhancer-driven lncRNA, as a regulator of inflammatory phenotypic transition in PASMCs under hypoxia, showing its role in stabilizing mitochondrial complex IV interactions and modulating lactylation of inflammatory gene promoters.
bioRxiv · May 7, 2024 · PreprintMolecular Biology