Systematic Chromosome Rearrangement Induced by CRISPR-Cas9 Reshapes the Genome and Transcriptome of Human Cells
Ying Liu, Guangwei Ma, Zeng-hong Gao, Jian Li, Jin Wang, Xiangping Zhu, Jiawen Yang, Yi Zhou, Kaishun Hu, Yin Zhang, Yabin Guo
This study uses CRISPR-Cas9 to induce systematic chromosome rearrangements in human cells, resulting in genome and transcriptome changes similar to those in tumors.
bioRxiv · Jun 15, 2021 · PreprintGenomics