This study presents nine high-quality Anas genomes to explore evolutionary relationships and domestication history, identifying key genetic factors and retrotransposon activity.

Cell Reports · Apr 1, 2025Peer-reviewedGenomics

Regulatory Mechanisms Orchestrating Cellular Diversity in Cd36+ Olfactory Sensory Neurons Revealed by Single-Cell Multi-omics Analysis.

Jiawen Yang, Peiyu Shi, Yiheng Li, Yachao Zuo, Tao Xu, Ziyang An, Dongjie Peng, Weixing Zhang, Yicong Xu, Zhongjie Tang, Anan Li, Jin Xu

bioRxiv · Sep 21, 2023 · PreprintNeuroscience

The swine spatiotemporal H3K27ac spectrum provides novel resources for exploring gene regulation related to complex traits and fundamental biological process

Yaling Zhu, Zhimin Zhou, Tao Huang, Zhen Zhang, Wanbo Li, Ziqi Ling, Tao Jiang, Jiawen Yang, Siyu Yang, Yanyuan Xiao, Carole Charlier, Michel Georges, Bin Juan Yang, Lusheng Huang

The paper characterizes the spatiotemporal H3K27ac landscape in pigs to identify regulatory elements and their associations with gene regulation and complex traits.

bioRxiv · Jul 28, 2021 · PreprintGenomics

Systematic Chromosome Rearrangement Induced by CRISPR-Cas9 Reshapes the Genome and Transcriptome of Human Cells

Ying Liu, Guangwei Ma, Zeng-hong Gao, Jian Li, Jin Wang, Xiangping Zhu, Jiawen Yang, Yi Zhou, Kaishun Hu, Yin Zhang, Yabin Guo

This study uses CRISPR-Cas9 to induce systematic chromosome rearrangements in human cells, resulting in genome and transcriptome changes similar to those in tumors.

bioRxiv · Jun 15, 2021 · PreprintGenomics