Jin Wang

This study develops a CRISPR-Cas12a-based system for rapid and sensitive NAD+ detection using acetylation and CobB reactivation.

This study shows that Cas12a activity is reversibly regulated by AcrVA5-mediated acetylation and CobB-mediated deacetylation, revealing a secondary safeguard for bacterial CRISPR defense systems.

This study uses CRISPR-Cas9 to induce systematic chromosome rearrangements in human cells, resulting in genome and transcriptome changes similar to those in tumors.

The paper develops HOLMESv2, a one-step nucleic acid detection platform combining LAMP and Cas12b for convenient and efficient detection.