Sortilin C-terminal fragment deposition depicts tangle-related nonamyloid neuritic plaque growth in Alzheimers disease
Qi‐Lei Zhang, Yan Wang, Sidiki Coulibaly, Zhong-Ping Sun, Xiao-Lu Cai, Tian Tu, Yu Liu, Aihua Pan, Mengchao Cui, Jim Manavis, Jian Wang, Yang Zhang, Xiao-Pin Wang, Xiao‐Xin Yan
The paper examines the spatial relationship between sortilin C-terminal fragments (sorfra) and neuritic plaques in Alzheimer's disease, finding they correlate with tau pathology and develop independently of amyloid-beta.
bioRxiv · Nov 11, 2024 · PreprintNeuroscience