Mengchao Cui

This study shows that wild-type PDI disassembles stress granules and prevents TDP-43 mislocalization and aggregation in ALS, while abnormal PDI leads to amyloid fibrils and neuronal death.

The paper examines the spatial relationship between sortilin C-terminal fragments (sorfra) and neuritic plaques in Alzheimer's disease, finding they correlate with tau pathology and develop independently of amyloid-beta.