Xiao‐Xin Yan

The China Brain Multi-omics Atlas Project (CBMAP) creates a comprehensive molecular reference map of over 1,000 human brains to address underrepresentation in East Asian populations and advance research on aging and neuropsychiatric disorders.

The paper examines early-onset β-amyloidosis in brains with hematological malignancies and cardiovascular diseases, finding vascular injury and axonal pathology associated with Aβ formation.

The paper identifies long-range mossy fiber sprouting and increased metabolic activity in the hippocampus of patients with drug-resistant mesial temporal lobe epilepsy.

The paper examines the spatial relationship between sortilin C-terminal fragments (sorfra) and neuritic plaques in Alzheimer's disease, finding they correlate with tau pathology and develop independently of amyloid-beta.

This study identifies population-specific eQTLs in brain tissues from European, African American, and Asian ancestry individuals, revealing new schizophrenia risk genes and variants missed in European-only datasets.

This study identifies eQTL and sQTL in East Asian brains, finds convergence in transcriptional regulatory architecture with European populations, and links these to schizophrenia risk genes and pathways.