Structure basis for single-strand nucleic acid targeting by IscB and variants
Chengtao Xu, Qi Yang, Xiaolin Niu, Ailong Ke
This paper reports cryo-EM structures of IscB bound to single-stranded nucleic acids, revealing a conformational checkpoint that regulates RNA targeting efficiency and introduces mutations to enhance it.
Nucleic Acids Research · Jun 6, 2026Peer-reviewedBiochemistry