Author

Ailong Ke

Cornell UniversityORCID 0000-0001-5957-7822Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Amy Wei-Lun TsaiiD· 1 shared Chengtao XuiD· 1 shared Elizabeth H. KelloggiD· 1 shared Eshan MehrotraiD· 1 shared Joseph E. PetersiD· 1 shared Jung-Un ParkiD· 1 shared Michael T. PetassiiD· 1 shared Qi Yang· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Amy Wei-Lun TsaiORCID

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2 papers

Recent·Most cited

BiochemistryNucleic Acids ResearchPeer-reviewedJun 6, 2026

Structure basis for single-strand nucleic acid targeting by IscB and variants

Chengtao Xu, Qi Yang, Xiaolin Niu, Ailong Ke

This paper reports cryo-EM structures of IscB bound to single-stranded nucleic acids, revealing a conformational checkpoint that regulates RNA targeting efficiency and introduces mutations to enhance it.

DOI 10.1093/nar/gkag607

experimental assayprotein structure prediction

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Molecular BiologySciencePeer-reviewedAug 12, 2021

Structural basis for target-site selection in RNA-guided DNA transposition systems

Jung-Un Park, Amy Wei-Lun Tsai, Eshan Mehrotra…·Elizabeth H. Kellogg

The paper uses cryo-EM to reveal how TnsC regulates target-site selection in CRISPR-associated transposition systems by transferring polarity information to the transposase.

78 citationstop 3%

experimental assay

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