Artificial Recombination of Nonribosomal Peptide Synthetases Rapidly Evolves Natural Products
Lin Zhong, Xingyan Wang, Xingxing Shi, Xianping Bai, Ying Liu, Hanna Chen, Seenivasan Boopathi, Xiaoqi Ji, Qingsheng Yang, Shengying Li, Rolf Müller, Qiang Tu, Youming Zhang, Xiaoying Bian
The paper introduces RACE, a method for rapidly evolving NRPSs through recombineering, generating novel peptides and uncovering new recombination sites.
bioRxiv · Feb 11, 2026 · PreprintSynthetic Biology