Xingyan Wang

In-silico cell sorting revealed granulocyte-specific single-cell-type gene expression from peripheral blood bulk expression data and its application as host response biomarkers to discriminate bacterial and viral infections

The paper develops an in-silico cell sorting method to identify granulocyte-specific gene expression biomarkers from bulk blood data, enabling discrimination between bacterial and viral infections.

Artificial Recombination of Nonribosomal Peptide Synthetases Rapidly Evolves Natural Products

The paper introduces RACE, a method for rapidly evolving NRPSs through recombineering, generating novel peptides and uncovering new recombination sites.

Changing the initiation unit of nonribosomal peptide synthetases to access underexplored biosynthetic potential

This paper introduces a strategy to activate silent NRPS biosynthetic gene clusters by swapping initiation units, successfully recovering three of six previously silent pathways and identifying five novel lipopeptides.

Monocyte single cell-type gene expression measured in peripheral blood by DIRECT LS-TA method: the ratio-based biomarkers of (IFI27/PSAP) showed superior performance than interferon score in triage patients with viral infection

This paper develops a ratio-based biomarker (DIRECT LS-TA) using monocyte-specific gene expression ratios in peripheral blood to improve viral infection triage, outperforming the IFN score in diagnostic accuracy.