Design of an ultrabright biosensor for dynamic imaging of kinase activity in cells
Xiaoquan Li, Sophia K. Tan, Chan-I Chung, A. Katherine Hatstat, Qian Cheng Zhao, Jingyu Luo, William F. DeGrado, Xiaokun Shu
The paper introduces NOVARK, an ultrabright biosensor for dynamic imaging of kinase activity, showing it can detect phosphorylation-induced assembly with higher brightness and dynamic range than existing methods.
Proceedings of the National Academy of Sciences · May 4, 2026Peer-reviewedBioengineering