Xiaokun Shu

The paper introduces NOVARK, an ultrabright biosensor for dynamic imaging of kinase activity, showing it can detect phosphorylation-induced assembly with higher brightness and dynamic range than existing methods.

The paper introduces GENTIS, a genetically encoded ionic-stress sensor, and shows that proton accumulation drives sleep in C. elegans through v-ATPase inhibition and membrane disassembly.

This study identifies how the topology of ER-microdomains and interactions with erlin-1 determine the proteolytic fate of P450s via ERAD or ERLAD.

This study shows YAP and Mediator form transcriptionally active condensates through charge patterning, enabling signal integration in stem cells.