Vaccination with mRNA-encoded membrane-bound HIV Envelope trimer induces neutralizing antibodies in animal models
Parham Ramezani-Rad, Christopher A. Cottrell, Ester Marina-Zárate, Alessia Liguori, Elise Landais, Jonathan L. Torres, Amber Myers, Jeong Hyun Lee, Sabyasachi Baboo, Claudia T. Flynn, Katherine R. McKenney, Eugenia Salcedo, Xiaoya Zhou, Oleksandr Kalyuzhniy, Erik Georgeson, , William R. Schief
Membrane-bound BG505 MD39.3 Env trimer delivered as mRNA-LNP reduced base-directed antibody responses in rabbits and macaques and elicited neutralizing antibodies, with memory B cell responses documented in macaques.
Science Translational Medicine · Jul 30, 2025Peer-reviewedImmunology✦ In-depth digest