Linoleic Acid-Lyso PG Axis promoting lipid droplet-mitochondria tethering by stabilizing Noncanonically Mitochondrial PPAR β/δ to Ameliorate Microglial Dysfunction in subarachnoid hemorrhage
Le-Xuan Zou, He Hu, Xun-Zhi Liu, junda shen, Sen Gao, Peng-Fei Ding, Kexin Tian, Xiaoxuan Dong, Xiaoyan Lu, Ruoyu Liu, Xiao-Jian Li, Zheng Peng, Xiang-Xin Chen, Chunhua Hang, Wei Li
This study identifies a lipid signaling pathway involving LA and LPG(16:0) that stabilizes PPAR{delta} on mitochondria, improving microglial function and reducing brain injury after SAH.
bioRxiv · Sep 2, 2026 · PreprintNeuroscience