Mechano-adaptation: Exercise-driven Piezo1 & Piezo2 augmentation and chondroprotection in articular cartilage
Xingyu Jing, Alexander Kotelsky, Yaxin Zhang, Robert T. Dirksen, Sandeep Mannava, Mark R. Buckley, Whasil Lee
This study shows exercise increases Piezo1 and Piezo2 in chondrocytes, reducing mechanical susceptibility to impact, with Piezo1 playing a key role in exercise-induced cartilage protection.
bioRxiv · Aug 2, 2024 · PreprintBioengineering