Whasil Lee

3D Light Sheet Microscopy Reveals Aging Osteoarthritis-associated Joint-innervated Nerve Remodeling in Mouse Knee Joints

This study uses 3D imaging to show that aging male mice with osteoarthritis have increased nociceptive nerve remodeling linked to pain, while females show no age-related changes.

Mechano-adaptation: Exercise-driven Piezo1 & Piezo2 augmentation and chondroprotection in articular cartilage

This study shows exercise increases Piezo1 and Piezo2 in chondrocytes, reducing mechanical susceptibility to impact, with Piezo1 playing a key role in exercise-induced cartilage protection.

Osteoarthritis: articular chondrocyte inflammatory signaling leads to enhanced gene expression and function of mechanotransduction channel Piezo1 as a pathogenic feedforwardmechanism

This study identifies a feedforward mechanism in osteoarthritis where IL-1-induced Piezo1 upregulation enhances mechanotransduction and contributes to cartilage damage.