Mechanism of branched actin assembly at microtubule tips downstream of Adenomatous Polyposis Coli (APC) protein
Xingyuan Fang, Nadia Efimova, Tatyana Svitkina
The paper identifies the APC - Asef1 - Cdc42 - N-WASP - Arp2/3 pathway as a mechanism by which microtubules regulate directional cell migration and neuron navigation through branched actin assembly at microtubule tips.
bioRxiv · Aug 3, 2026 · PreprintCell Biology