Tatyana Svitkina

The paper identifies the APC - Asef1 - Cdc42 - N-WASP - Arp2/3 pathway as a mechanism by which microtubules regulate directional cell migration and neuron navigation through branched actin assembly at microtubule tips.

This study identifies NM2A motor activity as a key component of bipolar filament depolymerization, working with tail-dependent mechanisms to enable NM2A turnover and NM2B reorganization in cells.

The paper identifies a TRPV4-dependent Ca2+ signaling pathway that regulates lamellipodia actin architecture and promotes cell migration through RhoA and formin-mediated actin assembly.

This study shows that NM2A's tail, phosphorylation sites, and motor domain synergistically enhance NM2B filament turnover and cell motility, while phosphomimetic NM2B tails only locally affect NM2B unless combined with NM2A.

The paper identifies the spatiotemporal coordination of WAVE and N-WASP with actin-bundling proteins to generate invasive protrusions during cell-cell fusion.

This study identifies CCDC32 as an endocytic accessory protein that stabilizes clathrin-coated pits and drives their invagination, with mutations linked to cardio-facio-neuro-developmental syndrome.