Pharmacology & ToxicologybioRxivPreprint
Chronic intermittent nicotine delivery with lung alveolar region-targeted aerosol technology produces circadian blood pharmacokinetics in rats resembling human smokers
Xuesi M. Shao, Siyu Liu, Eon S. Lee…·Xinmin S Xie
This paper develops a nicotine aerosol delivery system in rats that mimics human smoking pharmacokinetics, showing similar circadian nicotine and cotinine levels.
DOI 10.1101/195123