An accumbal cholinergic ISR-HCN2 axis sustains maladaptive cue motivation
Shihao Huang, Jingliang Zhang, Yue Li, Xinyou Lv, Zhihao Song, Ding Zengbo, Zhonghao Li, Yu Tian, Xiangyang Zang, Yuchuan Hu, Yixiao Luo, Haoyu Li, Jie Shi, Lin Lu, Zhuo Huang, Yan-Xue Xue
The paper identifies an ISR-HCN2 cholinergic mechanism in nucleus accumbens interneurons that sustains maladaptive cue-driven motivation and shows HCN blockade reduces cue-seeking behavior.
bioRxiv · Sep 24, 2026 · PreprintNeuroscience