Zhuo Huang

The paper identifies an ISR-HCN2 cholinergic mechanism in nucleus accumbens interneurons that sustains maladaptive cue-driven motivation and shows HCN blockade reduces cue-seeking behavior.

This paper benchmarks how reference genome choice affects human genome interpretation by comparing T2T references and finding ancestry-matched references provide more accurate variant discovery.

The paper introduces a support-based validation framework to correct assembly errors in diploid genomes using independent sequencing evidence.

This study evaluates the impact of population-specific reference genomes on variant calling in WES data from Chinese tumor samples, finding improved accuracy with the YAO reference.