The PTPRT pseudo-phosphatase domain is a denitrase
Yiqing Zhao, Shuliang Zhao, Yujun Hao, Benlian Wang, Peng Zhang, Xiujing Feng, Yicheng Chen, Jing Song, John Mieyal, Sanford Markowitz, Rob M. Ewing, Ronald A. Conlon, Masaru Miyagi, Zhenghe Wang
The study identifies the PTPRT pseudo-phosphatase domain as a denitrase that removes nitro-groups from tyrosine residues in paxillin, linking its dysfunction to tumor susceptibility.
bioRxiv · Dec 22, 2017 · PreprintCancer Biology