Zhenghe Wang

This study shows that combining PI3Kα and EZH1/2 inhibitors suppresses PIK3CA-mutated CRC by enhancing IL15-mediated NK cell activation.

This study shows efineptakin alfa (NT-I7) improves survival and induces tertiary lymphoid structures in murine lung tumors, potentially enhancing immunotherapy efficacy.

The paper develops a multiplexed mouse model to study TBX2 subfamily and Egr1 roles in Ras-driven lung cancer, finding Egr1 loss significantly increases tumor size and suggests immune dysregulation.

This study identifies STX1A and CDK1 as key factors in CTSG-mediated entry and killing of colorectal cancer cells through CRISPR/Cas9 screens.

The study identifies the PTPRT pseudo-phosphatase domain as a denitrase that removes nitro-groups from tyrosine residues in paxillin, linking its dysfunction to tumor susceptibility.