Inhibition of Pseudomonas aeruginosa-secreted protease IV reduces lung
Said M. Daboor, Lauren Burton, Trilok Neupane, Rhea Nickerson, Ashley Stueck, Carlie Charron, Shannen L. Grandy, Zhong Sun, Zui Wang, Tengfei Zhang, Qingping Luo, Christine Lehmann, Juan Zhou, Janet S. Lee, Jason J. LeBlanc, , Zhenyu Cheng
This study identifies PrpL as a key Pseudomonas aeruginosa protease that activates AP-1 and drives lung inflammation, and shows that inhibiting PrpL reduces cytokine production and clinical symptoms.
bioRxiv · Jul 28, 2026 · PreprintMicrobiology