Janet S. Lee

This study identifies PrpL as a key Pseudomonas aeruginosa protease that activates AP-1 and drives lung inflammation, and shows that inhibiting PrpL reduces cytokine production and clinical symptoms.

The paper investigates the conservation of Hippo signaling in the first lineage specification event across four mammalian species, finding that inhibiting the Hippo pathway drives ectopic trophectoderm initiation in all species.