Author

David N. Langelaan

Dalhousie UniversityORCID 0000-0001-9592-3075Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:zebrafish· 1

Frequent Co-Authors

Andrew J. RogeriD· 1 shared Ashley StueckiD· 1 shared Carlie Charron· 1 shared Christine LehmanniD· 1 shared Elias B. HabibiD· 1 shared Graham DellaireiD· 1 shared Ingo BraaschiD· 1 shared Janet S. LeeiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Andrew J. RogerORCID

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2 papers

Recent·Most cited

Inhibition of Pseudomonas aeruginosa-secreted protease IV reduces lung

Said M. Daboor, Lauren Burton, Trilok Neupane, Rhea Nickerson, Ashley Stueck, Carlie Charron, Shannen L. Grandy, Zhong Sun, Zui Wang, Tengfei Zhang, Qingping Luo, Christine Lehmann, Juan Zhou, Janet S. Lee, Jason J. LeBlanc, , Zhenyu Cheng

This study identifies PrpL as a key Pseudomonas aeruginosa protease that activates AP-1 and drives lung inflammation, and shows that inhibiting PrpL reduces cytokine production and clinical symptoms.

bioRxiv · Jul 28, 2026 · PreprintMicrobiology

PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates

Sabateeshan Mathavarajah, Kathleen L. Vergunst, Elias B. Habib, Shelby K. Williams, Raymond He, Maria Maliougina, Mika Park, Jayme Salsman, Stéphane Roy, Ingo Braasch, Andrew J. Roger, David N. Langelaan, Graham Dellaire

This study identifies PML and PML-like exonucleases as cytoplasmic suppressors of LINE-1 retrotransposition in jawed vertebrates, showing functional conservation across species.

Nucleic Acids Research · Feb 24, 2023Peer-reviewedMolecular Biology