Ligand-independent c-Met activation by HHLA2 drives hepatocellular carcinoma and predicts c-MET inhibitor efficacy
Xubo Huang, Runya Fang, Yuqian Pang, Zhe Zhang, Jieru Huang, Yuting Li, Tao Yuan, Yun Zeng, Zhao Yao, Silvia Vega-Rubín-de-Celis, Josephine W. Thinwa, Qisheng Zhang, Hao Shen, Jiahong Wang, Feng Shen, Yongjie Wei
This study identifies HHLA2 as a ligand-independent activator of c-Met in HCC, showing its role in tumor progression and its predictive value for c-Met inhibitor response.
Journal of Experimental & Clinical Cancer Research · May 20, 2025Peer-reviewedCancer Biology