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Xue‐Fei Wang

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Synthetic Biology· 1

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Approach:deep learning· 1 Approach:diffusion model· 1 Assay:protein sequence· 1 Research Focus:sequence-to-function modeling· 1 Approach:statistical model· 1

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Bo PengiD· 1 shared Dian‐Bing WangiD· 1 shared Jing SuniD· 1 shared Jing‐Ya Tang· 1 shared Sonam DorjeiD· 1 shared Tian‐Qi Sun· 1 shared Xian‐En ZhangiD· 1 shared Xuwo JiiD· 1 shared

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Bo PengORCID

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Synthetic BiologyAdvanced SciencePeer-reviewedSep 25, 2024

ProT-Diff: A Modularized and Efficient Approach to De Novo Generation of Antimicrobial Peptide Sequences through Integration of Protein Language Model and Diffusion Model

Xue‐Fei Wang, Jing‐Ya Tang, Jing Sun…·Dian‐Bing Wang

ProT-Diff generates novel antimicrobial peptides using a protein language model and diffusion model, producing 34 active peptides against bacteria with low toxicity.

55 citationstop 1%

protein sequencedeep learning

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