Bo Peng

The paper shows NeuroD1 does not convert microglia into neurons, instead causing apoptosis, using lineage tracing and single-cell RNA sequencing.

This study analyzes a diverse glioma cohort to show ancestry influences on survival, somatic alterations, and mutational processes in diffuse gliomas.

The paper shows microglia preserve fear memory by selectively pruning extinction-ensemble synapses through local signaling cues during memory retrieval.

This study enables the de novo biosynthesis of alpinetin in E. coli through directed evolution of a 5-O-methyltransferase, demonstrating its broad substrate specificity for O-methylated flavonoids.

ProT-Diff generates novel antimicrobial peptides using a protein language model and diffusion model, producing 34 active peptides against bacteria with low toxicity.

This study shows that microglia replacement through bone marrow transplantation halts disease progression in both mouse models and human patients with ALSP.

This study shows that microglia facilitate and stabilize the general anesthesia response by activating P2Y12 and calcium influx, without involving dendritic spine plasticity.

The paper identifies functional autapses in striatal parvalbumin interneurons but not in medium spiny neurons through electrophysiological recordings and simulations.

This study shows YTHDF2 negatively regulates RGC dendrite development and maintenance, with its knockout improving visual acuity and protecting against glaucoma in mice.

This study shows that blood vessel regression in the brain reduces neuronal activity by impairing mitochondrial metabolism and glutamate production.