Human DDIT4L intron retention contributes to cognitive impairment and amyloid plaque formation.
Kaicheng Li, Haixiang Shi, Zhen Li, Pu You, Jing Pan, Yi-Chuan Cai, Jin-Wen Li, Xue-Fei Ma, Shuo Zhang, Lei Diao, Bing Cai, Yang Lu, Haibo Wang, Ying Qing Mao, Liang Chen, Xu Zhang
This study identifies DDIT4L intron retention (DIR) as a contributor to cognitive impairment and amyloid plaque formation in Alzheimer's disease through interactions with gelsolin and GluA1.
Cell Discovery · Feb 10, 2025Peer-reviewedNeuroscience