Hydroxychloroquine-functionalized Ionizable Lipids Mitigate Inflammatory Responses in mRNA Therapeutics
Kepan Chen, Xuechun Li, Shuo Feng, Ye Li, Ting Jiang, Yan Liu, Na Guo, Xiaoling Zeng, Hongwei Yao, Min Qiu, Jing Lü, Jinzhong Lin
This study introduces HCQ-functionalized LNPs that reduce inflammation while maintaining mRNA delivery efficiency, showing promise for repeated dosing applications.
Journal of Controlled Release · Sep 25, 2025Peer-reviewedBioengineering