This study shows how a viral tRNA-like structure recruits host ribosomes for poly(A)-independent translation by binding to ribosomal subunits and substituting for poly(A) tails.

Nature Communications · Oct 29, 2026Peer-reviewedMolecular Biology

Rational and computation-assisted engineering of a compact and efficient StaCas9 genome editor

Miaomiao Li, Wenni You, Yuwen Tian, Jingtong Liu, Shengzhou Wang, J I N Y I Lin, Yongming Wang

This study identifies StaCas9 as a compact and efficient CRISPR-Cas9 variant with improved genome editing capabilities, particularly for therapeutic applications.

bioRxiv · Jul 21, 2026 · PreprintGenomics

A lateral linker histone binding mode scaffolds dinucleosome stacking in chromatin fibers

Youchao Wang, Shuoming Yang, Jiachen Wang, Xiaolong Wu, Dejian Zhou, Peng Liu, Ran Zha, Junzhe Sun, Jinru Zhang, Jinzhong Lin, Huabin Zhou, Jianhua Gan, Aiwu Dong

The paper determines the structure of Arabidopsis chromatin fibers with linker histone H1.3, revealing a noncanonical binding mode that scaffolds dinucleosome stacking.

bioRxiv · Mar 31, 2026 · PreprintMolecular Biology

Hydroxychloroquine-functionalized Ionizable Lipids Mitigate Inflammatory Responses in mRNA Therapeutics

Kepan Chen, Xuechun Li, Shuo Feng, Ye Li, Ting Jiang, Yan Liu, Na Guo, Xiaoling Zeng, Hongwei Yao, Min Qiu, Jing Lü, Jinzhong Lin

This study introduces HCQ-functionalized LNPs that reduce inflammation while maintaining mRNA delivery efficiency, showing promise for repeated dosing applications.

Journal of Controlled Release · Sep 25, 2025Peer-reviewedBioengineering

Synergically enhanced anti-tumor immunity of in vivo CAR by circRNA vaccine boosting

Yanyan Wang, Liangru Lin, Xinyue Wang, Jing Li, Qian Pan, Haomeng Kou, Jie Yin, Fei Gao, Xinyuan Liao, Chenchen Zhang, Qimeng Yin, Chengzhi Zhao, Xinyang Li, Jinzhong Lin, Yichi Xu, , Liang Qu

This study develops circRNA-based in vivo CAR and vaccines that synergistically enhance anti-tumor immunity in mice.

Cell Reports Medicine · Jul 24, 2025Peer-reviewedImmunology

Pyruvate kinase activates SARM1 to exacerbate axonal degeneration in diabetic peripheral neuropathy

Jingxuan Liu, Wenxi Li, Chenyu Li, Yuefeng Jiang, Wenjie Zhu, Zhe Zhang, Yong Juan Zhao, Jinzhong Lin, Wei Yu

This study identifies PKM as a metabolic activator of SARM1 in diabetic neuropathy, showing that inhibiting their interaction reduces axonal degeneration.

bioRxiv · May 28, 2025 · PreprintNeuroscience

Structural and functional interrelationship of histone H2A and its variants H2A.Z and H2A.W in Arabidopsis

Youchao Wang, Jiabing Wu, Shuoming Yang, Xiang Li, Jiachen Wang, Qinghe Lv, Xiaoyu Zhu, Guoliang Lu, Jinru Zhang, Wen‐Hui Shen, Bing Liu, Jinzhong Lin, Aiwu Dong

The paper investigates the structural and functional relationships between histone H2A and its variants H2A.Z and H2A.W in Arabidopsis using CRISPR/Cas9 mutants and cryo-EM, revealing redundancy and substitution capabilities.

Structure · May 12, 2025Peer-reviewedPlant Biology

Structural basis of translation in transcription-translation coupling

Jing Zhang, Guo‐Liang Lu, Wei Zhou, Vadim Molodtsov, Ziyun Cheng, Yu Zhang, Ruoxuan Li, Zhaoxuan Jiang, Mingxia Yang, Li Li, Huihui Shao, Wei Lin, Xiaogen Zhou, Richard H. Ebright, Jinzhong Lin, Chengyuan Wang

The paper reports cryo-EM structures of transcription-translation complexes (TTCs) at different stages of the translation cycle in E. coli, revealing structural changes and their functional implications.

bioRxiv · Mar 13, 2024 · PreprintMolecular Biology

Structure and Mechanism of a Structural and Functional Insights into the Action Mode of A Mitochondrial AAA+ DisaggregaseCLPB

Damu Wu, Yan Liu, Yuhao Dai, Guopeng Wang, Guoliang Lu, Yan Chen, Ningning Li, Jinzhong Lin, Ning Gao

This study reveals the structural and functional mechanism of CLPB, a mitochondrial AAA+ disaggregase, showing its unique assembly and substrate translocation properties.

bioRxiv · Mar 10, 2022 · PreprintMolecular Biology