Unwinding of RNA G-quadruplexes induces mouse and human totipotency
Yicong Dai, Xucong Teng, Qiushuang Zhang, Ronghui Li, Yuncong Wu, Difei Hu, Xiangdong Zhang, Yuhan Liu, Wenxuan Hu, Yeyin Li, Xin Meng, Na Zhang, Xuena Cao, Lili Dong, Chengjia Mi, , Jinghong Li
This study shows that unwinding RNA G-quadruplexes with FC3 induces and maintains totipotency in mouse and human cells, recapitulating 2-cell-stage features and enabling differentiation into embryonic and extraembryonic lineages.
bioRxiv · Feb 15, 2026 · PreprintCell Biology