Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology
Y. Morozumi, F. Mahayot, Y. Nakase, J. X. Soong, S. Yamawaki, F. Sofyantoro, Y. Imabata, A. H. Oda, M. Tamura, S. Kofuji, Y. Akikusa, K. Ohta, K. Shiozaki
This study shows that rapamycin enables fission yeast to grow at high temperatures by inhibiting TORC1, suggesting that TORC1 normally restricts high-temperature growth rather than promoting it.
bioRxiv · May 4, 2023Cell Biology