Addressing Enzymatic-Independent Tumor-Promoting Function of NAMPT via PROTAC-Mediated Degradation
G. Fan, X. Yang, B. Jiang, Y. Cang, H. Liu, X. Zhu, L. Chen
This study develops two PROTACs targeting NAMPT, showing they degrade the protein more effectively than FK866 in tumor cells, highlighting PROTACs as a better strategy for dual-function proteins.
bioRxiv · Sep 13, 2021 · PreprintBiochemistry